Rapid, Comprehensive TB Diagnosis and Resistance Profiling with Deeplex® Myc-TB: A Clinically Actionable NGS Approach

Timely diagnosis of Mycobacterium tuberculosis complex (MTBC) and its drug resistance profile is essential for initiating effective therapy, especially in the context of rising multidrug-resistant TB (MDR-TB) and the availability of new drugs and drug regimens. Targeted next generation sequencing is faster, cheaper and can be performed directly on the primary clinical sample (when compared to WGS) with good performance for samples with lower RT-PCR Ct and AFB Smear positivity. The Clear Dx Deeplex Myc-TB provides rapid and accurate detection of ID and drug resistance for MTBC, significantly reducing hands-on time by > 6 hours. This automated workflow can be easily adopted into routine workflow with no bioinformatics expertise required.