Effectiveness of COVID-19 mRNA Vaccines against COVID-19–Associated Hospitalization — Five Veterans Affairs Medical Centers, United States, February 1–August 6, 2021

Kristina L. Bajema et al. September 17, 2021

Morbidity and Mortality Weekly Report

Bajema K.L., Dahl R.M., Prill M.M., Meites E., Rodriguez-Barradas M.C., Marconi V.C., Beenhouwer D.O., Brown S.T., Holodniy M., Lucero-Obusan C., Rivera-Dominguez G., Morones R.G., Whitmire A., Goldin E.B., Evener S.L., Tremarelli M., Tong S., Hall A.J., Schrag S.J., McMorrow M., Kobayashi M., Verani J.R., Surie D. & SUPERNOVA COVID-19 Surveillance Group


mRNA COVID-19 vaccines are effective in preventing severe COVID-19 outcomes, including hospitalization. During February 1–August 6, 2021, vaccine effectiveness among U.S. veterans hospitalized at Five Veterans Affairs Medical Centers was 87%. mRNA COVID-19 vaccines remain highly effective, including during periods of widespread circulation of the SARS-CoV-2 B.1.617.2 (Delta) variant. Vaccine effectiveness in preventing COVID-19–related hospitalization was 80% among adults aged ≥65 years compared with 95% among adults aged 18–64 years. To protect against COVID-19–related hospitalization, all eligible persons should receive COVID-19 vaccination. Additional studies are needed to understand differences in COVID-19 vaccine effectiveness across age groups.

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