Effectiveness of COVID-19 mRNA Vaccines against COVID-19–Associated Hospitalization — Five Veterans Affairs Medical Centers, United States, February 1–August 6, 2021

Bajema K.L., Dahl R.M., Prill M.M., Meites E., Rodriguez-Barradas M.C., Marconi V.C., Beenhouwer D.O., Brown S.T., Holodniy M., Lucero-Obusan C., Rivera-Dominguez G., Morones R.G., Whitmire A., Goldin E.B., Evener S.L., Tremarelli M., Tong S., Hall A.J., Schrag S.J., McMorrow M., Kobayashi M., Verani J.R., Surie D. & SUPERNOVA COVID-19 Surveillance Group

Abstract

mRNA COVID-19 vaccines are effective in preventing severe COVID-19 outcomes, including hospitalization. During February 1–August 6, 2021, vaccine effectiveness among U.S. veterans hospitalized at Five Veterans Affairs Medical Centers was 87%. mRNA COVID-19 vaccines remain highly effective, including during periods of widespread circulation of the SARS-CoV-2 B.1.617.2 (Delta) variant. Vaccine effectiveness in preventing COVID-19–related hospitalization was 80% among adults aged ≥65 years compared with 95% among adults aged 18–64 years. To protect against COVID-19–related hospitalization, all eligible persons should receive COVID-19 vaccination. Additional studies are needed to understand differences in COVID-19 vaccine effectiveness across age groups.

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